Semax5mg–10mg
$55Lyophilized Semax supplied as a research reference standard.
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Sample Certificate of Analysis
Certificate of Analysis
Semax
Lot Number
SAMPLE-LOT
Purity (HPLC)
≥99%
Nominal Fill
5mg
Example of the certificate format issued for this compound. Purity and specification figures are the published values for Semax; the lot number and test date are shown only as placeholders. The certificate for the specific lot you receive is matched to the lot number printed on the vial. For laboratory research use only.
Characteristics
| Molecular Formula | C₃₇H₅₁N₉O₁₀S |
|---|---|
| CAS Number | 80714-61-0 |
| Molar Mass | 813.93 g/mol |
| Amino Acid Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Synonyms | Semax, ACTH (4-10) analog, Heptapeptide Semax |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and physiological saline |
| Organoleptic Profile | White lyophilized powder; odorless |
| Purity | ≥98% by HPLC |
| Storage Conditions | Store lyophilized at -20°C; protect from light; reconstituted solution stable at 2-8°C for up to 7 days |
How is Semax used in research?
Semax is a synthetic heptapeptide analog of the ACTH (4-10) fragment (Met-Glu-His-Phe-Pro-Gly-Pro), developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Unlike the parent ACTH molecule, Semax lacks hormonal (steroidogenic) activity while retaining and enhancing the neurotropic effects associated with the ACTH (4-10) sequence in preclinical models. The addition of the Pro-Gly-Pro C-terminal tripeptide confers resistance to enzymatic degradation and extends the peptide's biological activity in research models.
Preclinical research has characterized Semax's activity in cognitive-research preclinical models in animals, including learning, memory, and attention research markers. A key mechanism involves the upregulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in preclinical brain tissue, particularly in the hippocampus and prefrontal cortex. Studies have also shown that Semax modulates dopaminergic, serotonergic, and cholinergic neurotransmitter systems in preclinical systems.
Significant research has investigated Semax in neuroprotective assay models of ischemic stroke. Studies have demonstrated infarct-volume parameter modulation, improvements in neurological research readouts, and modulation of gene-expression patterns related to inflammatory and apoptotic markers following cerebral ischemia in research models. The peptide's ability to cross the blood-brain barrier via intranasal administration has facilitated preclinical research applications.
Areas of Study
Neuroprotective Assay Models
Demonstrated infarct-volume parameter modulation and neurological readouts in ischemic stroke research models through anti-apoptotic and inflammatory-marker modulation mechanisms.
Cognitive Enhancement
Investigated for improvements in learning, memory consolidation, and attention through modulation of multiple neurotransmitter systems.
BDNF Expression
Research shows upregulation of brain-derived neurotrophic factor and nerve growth factor in hippocampal and cortical regions.
Stroke Research Models
Extensively studied in cerebral ischemia research models with reported neuroprotective assay model activity and modulation of post-ischemic gene expression.
Neurotransmitter Modulation
Influences dopaminergic, serotonergic, and cholinergic pathways without the steroidogenic activity of the parent ACTH molecule.
References
- [1]Ashmarin IP, Nezavibatko VN, Levitskaya NG, et al. (1997). Design and investigation of an ACTH 4-10 analogue lacking D-amino acids and possessing nootropic properties. Neuroscience Research Communications, 21(2), 105-112.
- [2]Dolotov OV, Karpenko EA, Inozemtseva LS, et al. (2006). Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research, 1117(1), 54-60.
- [3]Gusev EI, Skvortsova VI, Dambinova SA, et al. (1997). Neuroprotective effects of semax in acute cerebral ischaemia. Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova, 97(6), 26-34.
- [4]Filippenkov IB, Stavchansky VV, Denisova AE, et al. (2020). Novel insights into the protective properties of ACTH(4-7)PGP (Semax) peptide at the transcriptome level following cerebral ischaemia-reperfusion in rats. Genes, 11(6), 681.
Disclaimer: Information provided for research reference only; not medical advice. Sold strictly for in-vitro research use.
Certificate of Analysis
Third-party verified
Every batch of Semax is independently tested by an A2LA-accredited (ISO 17025:2017) laboratory using HPLC-UV/VIS for purity and identity, with a batch-specific lot number. Results are published publicly.
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Frequently
Asked
Questions
Everything on purity, paperwork, shipping and the research-use-only terms. Still stuck? Read the full FAQ.
What does research use only mean?
Every compound we supply is a reference standard intended strictly for in-vitro laboratory research. It is not a drug or a supplement, and it is not for human or veterinary use, nor for diagnostic or therapeutic use.
How is purity verified?
Every lot is assayed by HPLC at an independent, accredited third-party laboratory. We publish the resulting Certificate of Analysis and link it to the lot number printed on the vial.
Where do I find the Certificate of Analysis?
Every lot has a public, batch-linked COA. Browse them all on the COA page, or open any product page and use the COA tab for that specific compound.
How quickly do orders ship?
Orders placed before 2PM EST ship the same business day. Shipments are cold-packed where required and fully tracked.
Do you ship internationally?
We currently ship within the United States. Requests from institutional buyers outside the US are handled case by case, so contact us before ordering.
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