Researchers studying CJC-1295 (No DAC) often combine
Save $45 with the CJC-1295 + Ipamorelin
All 2 compounds in a single lyophilized vial. Pre-blended at researcher-validated ratios for in-vitro co-incubation studies - no separate reconstitutions to manage.
Buying singles
- CJC-1295 (No DAC) 5mg$80
- Ipamorelin 5mg$65
CJC-1295 + Ipamorelin
5mg + 5mg
CJC-1295 (No DAC)5mg–10mg
$80Lyophilized CJC-1295 (No DAC) supplied as a research reference standard.
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Supplied to qualified labs and institutional buyers. Institutional use & eligibility
Frequently researched together
GLP-3 RT
20mg
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KLOW
80mg
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CJC-1295 + Ipamorelin
10mg + 10mg
$190
Bundle total
$535
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Example Certificate of Analysis
Certificate of Analysis
CJC-1295 (No DAC)
Lot Number
EXAMPLE-LOT
Purity (HPLC)
≥99%
Nominal Fill
5mg
Illustrative example of the certificate format issued for this compound. Purity and specification figures are the published values for CJC-1295 (No DAC); the lot number and test date are placeholders, not a real result. The certificate for the specific lot you receive is matched to the lot number printed on the vial. For laboratory research use only.
Characteristics
| Molecular Formula | C₁₅₂H₂₅₂N₄₄O₄₂ |
|---|---|
| CAS Number | 863288-34-0 |
| Molar Mass | 3367.97 g/mol |
| Amino Acid Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂ |
| Synonyms | Modified GRF 1-29, Mod GRF (1-29), CJC-1295 without DAC, Tetrasubstituted GRF (1-29) |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in sterile water and aqueous laboratory solvent |
| Organoleptic Profile | White lyophilized powder; odorless |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 21 days |
| Composition | Lyophilized Modified GRF (1-29) acetate salt |
How is CJC-1295 (No DAC) used in research?
CJC-1295 (no DAC), also known as Modified GRF (1-29) or Mod GRF (1-29), is a 30-amino acid synthetic GHRH analog supplied as a lyophilized reference standard for in-vitro GHRH-receptor binding and half-life characterization studies. Four amino acid substitutions (positions 2, 8, 15, and 27) relative to native GHRH(1-29) improve in-vitro stability against dipeptidyl peptidase-4 (DPP-4) and other protease panels used in laboratory characterization. This no-DAC form lacks the maleimidopropionic acid linker present in the Drug Affinity Complex variant.
Laboratory workflows characterize CJC-1295 no DAC as a GHRH-receptor ligand in recombinant GHRH-R expression systems and cultured somatotroph cell lines. Binding activates adenylyl cyclase through Gs-protein coupling; standard readouts include cAMP accumulation assays and PKA-substrate phosphorylation panels.
Researchers use this compound as a reference standard for in-vitro receptor-binding profiling, half-life characterization in synthetic serum stability assays, and two-receptor in-vitro co-activation studies alongside GHS-R1a reference ligands such as ipamorelin. Not for use in any living organism.
Areas of Study
In-Vitro GHRH-R Binding Assays
Used as a reference GHRH-R ligand in cAMP accumulation and competitive-binding assays on recombinant GHRH-R cell systems.
Half-Life Characterization
Profiled in synthetic serum and DPP-4 protease stability assays to characterize in-vitro degradation kinetics against parent GHRH(1-29).
Analytical Method Development
Applied as an identity, purity, and potency reference standard in HPLC and LC-MS comparability work.
Structural Analysis
Characterized by circular dichroism and mass spectrometry to confirm sequence identity and secondary-structure profile.
Two-Receptor In-Vitro Co-Activation Studies
Used alongside GHS-R1a reference ligands such as ipamorelin in cultured somatotroph cell systems for combined receptor-activation profiling.
References
- [1]Jetté L, Bhatt R, Bhatt DL, et al. (2005). hGRF1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats. Peptides, 26(5), 827-834.
- [2]Alba M, Fintini D, Bowers CY, et al. (2005). Effects of GHRH and GHRP-6, alone and in combination, on GH secretion in aged rats. Journal of Endocrinology, 185(3), 543-551.
- [3]Martin B, Lopez de Maturana R, Brenneman R, et al. (2005). Class II G protein-coupled receptors and their ligands in neuronal function and protection. NeuroMolecular Medicine, 7(1-2), 3-36.
Disclaimer: Information provided for research reference only; not medical advice. Sold strictly for in-vitro research use.
Certificate of Analysis
Third-party verified
Every batch of CJC-1295 (No DAC) is independently tested by an A2LA-accredited (ISO 17025:2017) laboratory using HPLC-UV/VIS for purity and identity, with a batch-specific lot number. Results are published publicly.
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from $170Frequently
Asked
Questions
Everything on purity, paperwork, shipping and the research-use-only terms. Still stuck? Read the full FAQ.
What does research use only mean?
Every compound we supply is a reference standard intended strictly for in-vitro laboratory research. It is not a drug or a supplement, and it is not for human or veterinary use, nor for diagnostic or therapeutic use.
How is purity verified?
Every lot is assayed by HPLC at an independent, accredited third-party laboratory. We publish the resulting Certificate of Analysis and link it to the lot number printed on the vial.
Where do I find the Certificate of Analysis?
Every lot has a public, batch-linked COA. Browse them all on the COA page, or open any product page and use the COA tab for that specific compound.
How quickly do orders ship?
Orders placed before 2PM EST ship the same business day. Shipments are cold-packed where required and fully tracked.
Do you ship internationally?
We currently ship within the United States. Requests from institutional buyers outside the US are handled case by case, so contact us before ordering.
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