5-Amino-1MQ5mg–50mg
$55Lyophilized 5-Amino-1MQ supplied as a research reference standard.
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Example Certificate of Analysis
Certificate of Analysis
5-Amino-1MQ
Lot Number
EXAMPLE-LOT
Purity (HPLC)
≥99%
Nominal Fill
5mg
Illustrative example of the certificate format issued for this compound. Purity and specification figures are the published values for 5-Amino-1MQ; the lot number and test date are placeholders, not a real result. The certificate for the specific lot you receive is matched to the lot number printed on the vial. For laboratory research use only.
Characteristics
| Molecular Formula | C₁₀H₁₁NO |
|---|---|
| CAS Number | 42464-96-0 |
| Molar Mass | 159.19 g/mol |
| Synonyms | 5-Amino-1-methylquinolin-2(1H)-one, 5-Amino-1-methyl-2-quinolinone |
| Physical Form | Crystalline powder |
| Solubility | Soluble in DMSO and methanol; sparingly soluble in water |
| Organoleptic Profile | Off-white to pale yellow crystalline powder |
| Composition | Small molecule NNMT inhibitor (not a peptide) |
| Purity | ≥98% by HPLC |
| Storage Conditions | Store at -20°C; protect from light and moisture |
How is 5-Amino-1MQ used in research?
5-Amino-1MQ (5-amino-1-methylquinolin-2(1H)-one) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide using S-adenosyl-L-methionine (SAM) as the methyl donor. NNMT is highly expressed in white adipose tissue, and its overexpression has been associated in preclinical models with adiposity-parameter shifts and metabolic-parameter dysregulation markers. By inhibiting NNMT, 5-Amino-1MQ is proposed to increase the intracellular availability of NAD+ (nicotinamide adenine dinucleotide) and SAM, two critical cofactors involved in cellular energy metabolism and epigenetic regulation.
Preclinical research published by Neelakantan and colleagues characterized 5-Amino-1MQ in diet-induced rodent research models, reporting shifts in body-mass and white-adipose-tissue parameter readouts without effects on food-intake markers. The mechanism was attributed to increased cellular energy expenditure through enhanced NAD+ availability, which activates sirtuin-dependent metabolic pathways. Additionally, NNMT inhibition was shown to reduce lipogenesis in adipocyte cell lines and to alter the expression of genes involved in lipid metabolism and adipocyte differentiation.
The relationship between NNMT and metabolic regulation extends beyond adipose tissue. Research has identified NNMT as a regulator of the methionine cycle and one-carbon metabolism, with implications for epigenetic regulation through SAM-dependent methylation reactions. Studies have also explored NNMT's role in cancer metabolism, where the enzyme is overexpressed in several tumor types and may contribute to metabolic reprogramming.
Areas of Study
NNMT Inhibition
Selective inhibitor of nicotinamide N-methyltransferase, an enzyme linking NAD+ metabolism, methylation pathways, and adipose tissue function.
NAD+ Regulation
Increases intracellular NAD+ availability by preventing NNMT-mediated nicotinamide methylation, supporting sirtuin-dependent metabolic pathways.
Adipocyte Biology
Reduces lipogenesis and alters adipocyte differentiation gene expression; preclinical models show reduced adipose tissue mass without appetite suppression.
Energy Metabolism
Promotes increased cellular energy expenditure through NAD+-dependent mechanisms and modulation of one-carbon metabolism.
References
- [1]Neelakantan H, Brightwell CR, Graber TG, et al. (2019). Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochemical Pharmacology, 163, 481-492.
- [2]Neelakantan H, Wang HY, Vance V, et al. (2017). Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology, 147, 141-152.
- [3]Kraus D, Yang Q, Kong D, et al. (2014). Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature, 508(7495), 258-262.
- [4]Pissios P. (2017). Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends in Endocrinology & Metabolism, 28(5), 340-353.
Disclaimer: Information provided for research reference only; not medical advice. Sold strictly for in-vitro research use.
Certificate of Analysis
Third-party verified
Every batch of 5-Amino-1MQ is independently tested by an A2LA-accredited (ISO 17025:2017) laboratory using HPLC-UV/VIS for purity and identity, with a batch-specific lot number. Results are published publicly.
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Asked
Questions
Everything on purity, paperwork, shipping and the research-use-only terms. Still stuck? Read the full FAQ.
What does research use only mean?
Every compound we supply is a reference standard intended strictly for in-vitro laboratory research. It is not a drug or a supplement, and it is not for human or veterinary use, nor for diagnostic or therapeutic use.
How is purity verified?
Every lot is assayed by HPLC at an independent, accredited third-party laboratory. We publish the resulting Certificate of Analysis and link it to the lot number printed on the vial.
Where do I find the Certificate of Analysis?
Every lot has a public, batch-linked COA. Browse them all on the COA page, or open any product page and use the COA tab for that specific compound.
How quickly do orders ship?
Orders placed before 2PM EST ship the same business day. Shipments are cold-packed where required and fully tracked.
Do you ship internationally?
We currently ship within the United States. Requests from institutional buyers outside the US are handled case by case, so contact us before ordering.
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